Poor responders in in vitro fertilization (IVF) therapy: the challenge continues
نویسنده
چکیده
Poor responders represent more than a third of women undergoing assisted reproduction. Typically they are patients with advanced maternal age and low ovarian reserve. However, there is a younger group that unexpectedly demonstrates impaired response to controlled ovarian hyperstimulation. The etiologies in many of these cases are still unclear. In our program, the determination of basal cycle day 3 serum FSH, LH and E2 levels, measurement of AMH, and the estimation of the basal antral follicular count by transvaginal ultrasonography, are the preferred screening tests for ovarian reserve in all IVF patients, and together with the woman's age, determine the ovarian stimulation regimen to be chosen for the cycle treatment. In spite of a -variety of protocols and adjuvant therapies of unproven benefit, these patients have compromised outcomes and continue to represent a challenge to reproductive endocrinologists.
منابع مشابه
I-27: Management of Poor Responders:Current and Past Recommended Strategy
The management of poor responders in IVF cycles is extremely controversial due to their inadequate response to controlled ovarian hyperstimulation.. A low ovarian response may be idiopathic or may be associated with many different factors including age, diminished ovarian reserve, endometriosis and prior ovarian surgery, and a reported incidence 9-24% of IVF patients. Several strategies have be...
متن کاملنشانگرهای پاسخ تخمدانی در تحریک تخمکگذاری جهت سیکل لقاح خارج رحمی
Markers of Ovarian Response in the Induction of Ovulation for IVF Cycle S. Esmaeilzadeh [1] , M. Faramarzi [2] Received: 24/11/07 Sent for Revision: 06/03/08 Received Revised Manuscript: 27/11/08 Accepted: 16/03/09 Background and Objectives: Poor responding of ovaries to ovarian stimulating drugs is one of the most important problems in assisted reproductive technologies. The aim ...
متن کاملResurgence of Minimal Stimulation In Vitro Fertilization with A Protocol Consisting of Gonadotropin Releasing Hormone-Agonist Trigger and Vitrified-Thawed Embryo Transfer
Minimal stimulation in vitro fertilization (mini-IVF) consists of a gentle controlled ovarian stimulation that aims to produce a maximum of five to six oocytes. There is a misbelief that mini-IVF severely compromises pregnancy and live birth rates. An appraisal of the literature pertaining to studies on mini-IVF protocols was performed. The advantages of minimal stimulation protocols are report...
متن کاملComparison of The Effectiveness of Clomiphene Citrate versus Letrozole in Mild IVF in Poor Prognosis Subfertile Women with Failed IVF Cycles
Background Our objective was to evaluate the effectiveness of clomiphene citrate (CC) vs. letrozole (L) plus human menopausal gonadotropin (hMG) in gonadotropin releasing hormone (GnRH) antagonist protocol in poor prognosis women with previous failed ovarian stimulation undergoing intracytoplasmic sperm injection (ICSI). MaterialsAndMethods This retrospective cohort study included cycles with C...
متن کاملComment on “The Role of Overweight and Obesity in In Vitro Fertilization Outcomes of Poor Ovarian Responders”
We read with interest the study by Vural et al. [1], who aimed to retrospectively explore the effects of overweight and obesity on IVF outcomes of poor ovarian responders (POR). While the oocyte maturity, total gonadotropin doseduration, and cycle cancellation rates were similar, they observed significantly lower fertilization and clinical pregnancy rates in obese compared to normal and overwei...
متن کامل